Article
SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors.
Cancer research communications - 1 Dec 2024
Palmer Theron, Kessler Michael D, Shao Xiaoshan M, Balan Archana, Yarchoan Mark, Zaidi Neeha, Lopez-Vidal Tamara Y, Saeed Ali M, Gore Jessica, Azad Nilofer S, Jaffee Elizabeth M, Favorov Alexander V, Anagnostou Valsamo, Karchin Rachel, Gaykalova Daria A, Fertig Elana J, Danilova Ludmila
Abstract excerpt
ABSTRACT: Aberrant alternative splicing can generate neoantigens, which can themselves stimulate immune responses and surveillance. Previous methods for quantifying splicing-derived neoantigens are limited by independent references and potential batch effects. Here, we introduce SpliceMutr, a bioinformatics approach and pipeline for identifying splicing-derived neoantigens from tumor and normal data. SpliceMutr...
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