Article

<i>Brca1</i> heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolism

2026-02-26

Abstract excerpt

<h4>Summary</h4> Carrying a germline mutation in BRCA1 is associated with an increased risk of several cancers, including breast and ovarian. Our recent work has demonstrated that obesity is associated with elevated levels of DNA damage in breast glands in this high-risk population. BRCA1 is a canonical tumor suppressor gene primarily recognized for its role in DNA damage repair, yet emerging evidence suggests...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5690b31e-0c3b-5d91-b1e6-77ba29bd4b22
DOI: 10.64898/2026.02.25.708005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Brca1</i> heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolismDOI 10.64898/2026.02.25.708005Read

Obesity promotes breast epithelium DNA damage in BRCA mutation carriersSemantic proximity Read

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.Semantic proximity Read

Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.Semantic proximity Read

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progressionSemantic proximity Read

Cisplatin exposure alters long-term metabolic phenotype of male, but not female, high-fat diet-fed miceSemantic proximity Read

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.Semantic proximity Read

BRCA1: An Endocrine and Metabolic Regulator.Semantic proximity Read

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in miceSemantic proximity Read

Mouse models of BRCA1 and their application to breast cancer research.Semantic proximity Read

Sex-Specific Peripheral Metabolic and Central Hypothalamic Responses in a CD1 Mouse Model of Diet-Induced ObesitySemantic proximity Read

Loss of <i>RREB1</i> reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytesSemantic proximity Read

Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in miceSemantic proximity Read