Article

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

2022-08-02

Abstract excerpt

Obesity is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated bodyweight is a risk factor for women with a germline mutation in BRCA1 or BRCA2 is less clear due to inconsistent findings from epidemiological studies and lack of mechanistic studies in this population. Here, we show that DNA damage in normal breast epithelium of BRCA mutation carrie...

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Literature Corpus work: 8d672872-02ff-547e-bc78-f2a5fc1d3b4e
DOI: 10.1101/2022.07.29.502090

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