Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.

doi:10.1126/scitranslmed.ade1857

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Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.

Science translational medicine - 22 Feb 2023

Bhardwaj Priya, Iyengar Neil M, Zahid Heba, Carter Katharine M, Byun Dong Jun, Choi Man Ho, Sun Qi, Savenkov Oleksandr, Louka Charalambia, Liu Catherine, Piloco Phoebe, Acosta Monica, Bareja Rohan, Elemento Olivier, Foronda Miguel, Dow Lukas E, Oshchepkova Sofya, Giri Dilip D, Pollak Michael, Zhou Xi Kathy, Hopkins Benjamin D, Laughney Ashley M, Frey Melissa K, Ellenson Lora Hedrick, Morrow Monica, Spector Jason A, Cantley Lewis C, Brown Kristy A

Abstract excerpt

Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI is a risk factor for women with a germline mutation in BRCA1 or BRCA2 is less clear because of inconsistent findings from epidemiological studies and a lack of mechanistic studies in this population. Here, we show that DNA damage in normal...

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Identifiers

PMID: 36812344
DOI: 10.1126/scitranslmed.ade1857
PMCID: PMC10557057

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