Article

Cisplatin exposure alters long-term metabolic phenotype of male, but not female, high-fat diet-fed mice

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Cancer survivors face an increased risk of metabolic complications compared to the general population. Our group demonstrated that cisplatin, a platinum-based chemotherapeutic agent, robustly disrupts insulin secretion in vitro in mouse and human islets, and reduces plasma insulin levels in mice 2 weeks post- in vivo exposure. The long-term effects of in vivo cisplatin exposure alongside a pr...

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Literature Corpus work: beeffa2d-74c4-5640-ae86-5dfc7f32706f
DOI: 10.64898/2026.04.10.717733

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