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Article

The Emerging Role of the Molecular Chaperone Clusterin in Parkinson’s Disease

1 Jul 2025

Abstract excerpt

Clusterin (CLU) is a heterodimeric, ATP-independent molecular chaperone that exhibits high expression in the brain. While CLU primarily functions in the extracellular environment, its chaperone activity in the intracellular compartment under different stress conditions, as well as its involvement in various signaling networks, has been demonstrated. CLU has been extensively associated with Alzheimer's Disease;...

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PMID: 40650133
DOI: 10.3390/ijms26136351

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