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Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

1 Aug 2008

Abstract excerpt

BACKGROUND: The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that can be associated with a C-terminal domain. TRIM genes are involved in ubiquitylation and are implicated in a variety of human pathologies, from Mendelian inherited disorders to cancer, and are also involved in cellular response to viral infection. RESULTS: Here we defined the...

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PMID: 18673550
DOI: 10.1186/1471-2148-8-225

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