Article
Human coding synonymous single nucleotide polymorphisms at ramp regions of mRNA translation.
PloS one - 1 Jan 2013
Li Quan, Qu Hui-Qi
Abstract excerpt
According to the ramp model of mRNA translation, the first 50 codons favor rare codons and have slower speed of translation. This study aims to detect translational selection on coding synonymous single nucleotide polymorphisms (sSNP) to support the ramp theory. We investigated fourfold degenerate site (FFDS) sSNPs with A ↔ G or C ↔ T substitutions in human genome for distribution bias of synonymous codons (SC),...
Topics
- Codon
- Genome, Human
- Humans
- Models, Genetic
- Point Mutation
- Polymorphism, Single Nucleotide
- Protein Biosynthesis
- RNA, Messenger
- Selection, Genetic