Article
FAM111A protects replication forks from protein obstacles via its trypsin-like domain.
Nature communications - 12 Mar 2020
Kojima Yusuke, Machida Yuka, Palani Sowmiya, Caulfield Thomas R, Radisky Evette S, Kaufmann Scott H, Machida Yuichi J
Abstract excerpt
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms may exist to cope with the diversity of protein obstacles. Here, we show that FAM111A, a...
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