Article

Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets

2025-10-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Alzheimer’s disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck. <h4>Methods</h4> We applied an integrative screening framework to assess 29 candidate targets from risk-enriched biological domains. Using disease-relevant mur...

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Literature Corpus work: 55f7ad69-1ff9-5efb-b3cc-556dd9f61cfc
DOI: 10.1101/2025.10.16.682926

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