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Article

Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2025

Cary Gregory A, Li Qianjin, Wiley Jesse C, Paisie Carolyn A, Du Yuhong, Zoeller Elizabeth L, Duong Duc, Fu Haian, Seyfried Nicholas T, Levey Allan I, Betarbet Ranjita, Carter Gregory W

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck. METHODS: We applied an integrative screening framework to assess 29 candidate targets from risk-enriched biological domains. Using disease-relevant murine BV2 microglial cell lines with...

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PMID: 41388808
DOI: 10.1002/alz.71008
PMCID: PMC12701361

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