Article
Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis.
Cell - 30 Oct 2025
Wang Erming, Yu Kaiwen, Cao Jiqing, Wang Minghui, Katsel Pavel, Song Won-Min, Wang Zhen, Li Yuxin, Wang Xusheng, Wang Qian, Xu Peng, Yu Gefei, Zhu Li, Geng Jia, Habibi Parnian, Qian Lu, Tuck Tony, Li Aiqun, Tcw Julia, Roussos Panos, Brennand Kristen J, Haroutunian Vahram, Johnson Erik C B, Seyfried Nicholas T, Levey Allan I, Bennett David A, Peng Junmin, Cai Dongming, Zhang Bin
Abstract excerpt
The molecular mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common form of dementia, remain poorly understood. Proteomics offers a crucial approach to elucidating AD pathogenesis, as alterations in protein expression are more directly linked to phenotypic outcomes than changes at the genetic or transcriptomic level. In this study, we develop multiscale proteomic network models for...
Topics
- Proteomics
- Protein Interaction Maps
- Humans
- Alzheimer Disease
- Brain
- Genotype
- Apolipoproteins E
- Proteome
- Animals