Article
CNS myelination requires cytoplasmic dynein function.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2015
Yang Michele L, Shin Jimann, Kearns Christina A, Langworthy Melissa M, Snell Heather, Walker Macie B, Appel Bruce
Abstract excerpt
BACKGROUND: Cytoplasmic dynein provides the main motor force for minus-end-directed transport of cargo on microtubules. Within the vertebrate central nervous system (CNS), proliferation, neuronal migration, and retrograde axon transport are among the cellular functions known to require dynein. Accordingly, mutations of DYNC1H1, which encodes the heavy chain subunit of cytoplasmic dynein, have been linked to...
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