Article

Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clusters

2021-06-10

Abstract excerpt

Abundant polyclonal T cells infiltrate chronic inflammatory diseases and characterization of these cells is needed to distinguish disease-driving from bystander immune cells. Here, we investigated 52,000 human cutaneous transcriptomes of non-communicable inflammatory skin diseases (ncISD) using spatial transcriptomics. Despite the expected T cell infiltration, we observed only 1-10 pathogenic T cell cytokine per s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55f3ce51-2e06-52f1-9d24-9df797ade0f5
DOI: 10.1101/2021.06.10.447894

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clustersDOI 10.1101/2021.06.10.447894Read

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseasesSemantic proximity Read

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory DiseaseSemantic proximity Read

Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disordersSemantic proximity Read

Maximizing the Utility of Transcriptomics Data in Inflammatory Skin DiseasesSemantic proximity Read

A scRNA-seq atlas of chronic inflammatory skin diseasesSemantic proximity Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

Single‐cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasisSemantic proximity Read

Single cell immunophenotyping identifies CD8 + GZMK + IFNG + T cells as a key immune population in cutaneous Lyme diseaseSemantic proximity Read

New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity Read

Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areataSemantic proximity Read

T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblastsSemantic proximity Read

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystemsSemantic proximity Read