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Single cell immunophenotyping identifies CD8 + GZMK + IFNG + T cells as a key immune population in cutaneous Lyme disease

2025-06-12

Abstract excerpt

The skin lesion erythema migrans (EM) is the first clinical sign of Lyme disease, an infection due to the tick-transmitted bacterium Borrelia burgdorferi ( Bb ). Previously, we used scRNA-Seq to characterize the cutaneous immune response in the EM lesion, focusing on B cells. Here, with an expanded sample size, we profiled T cell responses in EM lesions compared to autologous uninvolved skin. In addition to CD4...

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Literature Corpus work: 25ee18bd-3d35-5bff-a0ea-612bcfdaef15
DOI: 10.1101/2025.06.09.658661

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Single cell immunophenotyping identifies CD8 + GZMK + IFNG + T cells as a key immune population in cutaneous Lyme diseaseDOI 10.1101/2025.06.09.658661Read

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Single cell immunophenotyping identifies CD8 <sup>+</sup> GZMK <sup>+</sup> IFNG <sup>+</sup> T cells as a key immune population in cutaneous Lyme disease

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