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Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

28 Nov 2014

Abstract excerpt

BACKGROUND: Synapses are fundamental components of brain circuits and are disrupted in over 100 neurological and psychiatric diseases. The synapse proteome is physically organized into multiprotein complexes and polygenic mutations converge on postsynaptic complexes in schizophrenia, autism and intellectual disability. Directly characterising human synapses and their multiprotein complexes from post-mortem tissue...

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PMID: 25429717
DOI: 10.1186/s13041-014-0088-4

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