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Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer’s Disease

2025-01-13

Abstract excerpt

<h4> A bstract </h4> Synapse dysfunction is an early event in Alzheimer’s disease (AD) caused by various factors such as Amyloid beta, p-tau, inflammation, and aging. However, the exact molecular mechanism of synapse dysfunction in AD is largely unknown. To understand this, we comprehensively analyzed the synaptosome fraction in postmortem brain samples from AD patients and cognitively normal individuals. We co...

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Literature Corpus work: 1c0cd2d3-85ae-57b9-9740-d0d31d533950
DOI: 10.1101/2025.01.09.631584

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