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Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in <i>C9ORF72</i> -Frontotemporal Dementia

2026-07-27

Abstract excerpt

<h4>ABSTRACT</h4> Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are linked neurodegenerative diseases characterized by both synaptic dysfunction and TDP-43 pathology. A hexanucleotide repeat expansion (HRE) in the C9ORF72 (C9) gene represents the most common genetic cause of FTD and ALS, yet the synapse-specific mechanisms underlying disease pathogenesis remain poorly understood. Here, we...

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Literature Corpus work: 94cb1db2-870b-5477-b82d-b1ee27671423
DOI: 10.64898/2026.07.26.740405

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