Article

Behavioral and metabolic and effects of ABCG4 KO in the APPswe,Ind (J9) mouse model of Alzheimer’s disease

2023-06-08

Abstract excerpt

<title>Abstract</title> <p>The pathogenesis of Alzheimer’s disease (AD) is complex and involves an imbalance between production and clearance of amyloid-ß peptides (Aß), resulting in accumulation of Aß in senile plaques. Hypercholesterolemia is a major risk factor for developing AD, with cholesterol shown to accumulate in senile plaques and increase production of Aß. ABCG4 is a member of the ATP-binding cassette...

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Literature Corpus work: 55ed54e3-107a-5a25-8506-24603d377671
DOI: 10.21203/rs.3.rs-3014093/v1

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