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Article

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Sept 2012

Fitz Nicholas F, Cronican Andrea A, Saleem Muzamil, Fauq Abdul H, Chapman Robert, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) transporter regulates cholesterol efflux and is an essential mediator of high-density lipoprotein (HDL) formation. In amyloid precursor protein (APP) transgenic mice, Abca1 deficiency increased amyloid deposition in the brain paralleled by decreased levels of Apolipoprotein E (ApoE). The APOEε4 allele is the major genetic risk factor of sporadic Alzheimer's disease...

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Source

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Identifiers

PMID: 22993429
DOI: 10.1523/JNEUROSCI.1937-12.2012
PMCID: PMC3646580

Genes

APP
ABCA1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.PMID 22993429Read ↗

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