Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Sept 2012

Fitz Nicholas F, Cronican Andrea A, Saleem Muzamil, Fauq Abdul H, Chapman Robert, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) transporter regulates cholesterol efflux and is an essential mediator of high-density lipoprotein (HDL) formation. In amyloid precursor protein (APP) transgenic mice, Abca1 deficiency increased amyloid deposition in the brain paralleled by decreased lev...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microdialysis
Share to Apolipoprotein E3
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Conditioning, Psychological

Share to Maze Learning

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 22993429
DOI: 10.1523/JNEUROSCI.1937-12.2012
PMCID: PMC3646580

Genes

APP
ABCA1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22993429-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.PMID 22993429Read ↗

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.Semantic proximity Read ↗

ABCA1 activity is associated with reduced Alzheimer’s Disease risk in APOE ε4 non-carriersSemantic proximity Read ↗

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.Semantic proximity Read ↗

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.Semantic proximity Read ↗

The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s diseaseSemantic proximity Read ↗

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.Semantic proximity Read ↗

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.Semantic proximity Read ↗

Behavioral and metabolic and effects of ABCG4 KO in the APPswe,Ind (J9) mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphismsSemantic proximity Read ↗

Human APOE variants in Alzheimer’s Disease and type III hyperlipoproteinemia: insights from Long-Evans knock-in rat models with humanized App and APOESemantic proximity Read ↗

ABCA7 and Pathogenic Pathways of Alzheimer’s DiseaseSemantic proximity Read ↗

ABC Transporters Are Key Players in Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.