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A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL−F/NL−F knock‐in mouse model

10 Jul 2021

Abstract excerpt

Abstract Insulin resistance and diabetes mellitus are major risk factors for Alzheimer's disease (AD), and studies with transgenic mouse models of AD have provided supportive evidence with some controversies. To overcome potential artifacts derived from transgenes, we used a knock‐in mouse model, AppNL−F/NL−F, which accumulates Aβ plaques from 6 months of age and shows mild cognitive impairment at 18 months of...

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PMID: 34245097
DOI: 10.1111/acel.13429

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