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Article

Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice.

Neurobiology of aging - 1 Jan 2014

Papadopoulos Panayiota, Tong Xin-Kang, Hamel Edith

Abstract excerpt

Cognitive and cerebrovascular deficits are 2 landmarks of Alzheimer's disease (AD) to target for effective therapy. Here, we evaluated the efficacy of simvastatin in bitransgenic A/T mice overexpressing a mutated form of the human amyloid precursor protein (APP(Swe,Ind)) and a constitutively active form of transforming growth factor-β1. These mice feature the AD amyloid beta (Aβ) and cerebrovascular pathology....

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Source

Identifiers

PMID: 23954171
DOI: 10.1016/j.neurobiolaging.2013.07.010

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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