Article

mfSuSiE enables multi-cell-type fine-mapping and multi-omic integration of chromatin accessibility QTLs in aging brain

2025-11-28

Abstract excerpt

Molecular quantitative trait locus (QTL) studies increasingly profile chromatin accessibility, histone modifications, DNA methylation, RNA modifications such as N6-methyladenosine (m6A), and transcription across multiple cell types using high-throughput sequencing, generating dense base-pairresolved measurements. The conventional approach of testing each variant against each molecular feature independently suffers...

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Literature Corpus work: 55e04c2c-cc7c-59ec-a931-091bbf4c79d0
DOI: 10.1101/2025.11.25.690439

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