Article
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Cell - 5 Apr 2018
Hoadley Katherine A, Yau Christina, Hinoue Toshinori, Wolf Denise M, Lazar Alexander J, Drill Esther, Shen Ronglai, Taylor Alison M, Cherniack Andrew D, Thorsson Vésteinn, Akbani Rehan, Bowlby Reanne, Wong Christopher K, Wiznerowicz Maciej, Sanchez-Vega Francisco, Robertson A Gordon, Schneider Barbara G, Lawrence Michael S, Noushmehr Houtan, Malta Tathiane M, Stuart Joshua M, Benz Christopher C, Laird Peter W
Abstract excerpt
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.