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PathMethy: an interpretable AI framework for cancer origin tracing based on DNA methylation

23 Sept 2024

Abstract excerpt

Despite advanced diagnostics, 3%-5% of cases remain classified as cancer of unknown primary (CUP). DNA methylation, an important epigenetic feature, is essential for determining the origin of metastatic tumors. We presented PathMethy, a novel Transformer model integrated with functional categories and crosstalk of pathways, to accurately trace the origin of tumors in CUP samples based on DNA methylation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39391931
DOI: 10.1093/bib/bbae497

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