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Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma

12 Nov 2024

Abstract excerpt

Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic potential. Despite the predominance of malignant cells within the tumor microenvironment, the heterogeneity and underlying molecular features remain to be fully characterized. We analyzed single-cell transcriptomic profiling of 37,660 malignant cells from 17 UM tumors . A consensus non-negative factorization algorithm was used to decipher...

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PMID: 39533334
DOI: 10.1186/s12967-024-05831-2

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