Article

Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders

2023-07-07

Abstract excerpt

GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since its role in humans is not fully defined, we used an unbiased computational approach to assess the clinical significance of rare GPR37L1 genetic variants found among 51,289 whole exome sequences from the DiscovEHR cohort. Briefly, rare GPR37L1 coding variants were binned according to predicted p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04ac2617-3d71-5afe-9462-19625c094342
DOI: 10.1101/2023.07.05.547546

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rare GPR37L1 variants reveal potential roles in anxiety and migraine disordersDOI 10.1101/2023.07.05.547546Read

Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.Semantic proximity Read

Rare variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associationsSemantic proximity Read

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.Semantic proximity Read

Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK BiobankSemantic proximity Read

G protein-coupled receptor (GPCR) gene variants and human genetic disease.Semantic proximity Read

Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.Semantic proximity Read

Identification and molecular characterization of missense mutations in orphan GPCR GPR61 occurring in severe obesitySemantic proximity Read

The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological SignificanceSemantic proximity Read

Pharmacogenetics of the G protein-coupled receptors.Semantic proximity Read

Migraine genetics: current findings and future lines of research.Semantic proximity Read

Exploring human rare disease variants from a multidimensional perspective illuminates receptor – G protein coupling diversitySemantic proximity Read

Genetics of migraine.Semantic proximity Read