Article

Gastric epithelium from <i>BRCA1</i> and <i>BRCA2</i> carriers harbors increased double-stranded DNA damage and augmented growth

2025-10-03

Abstract excerpt

An accumulating body of evidence suggests carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting homologous recombination to repair double-stranded DNA breaks. The aim of this investigation was to identify differences within the gastric epithelium and in patient-derived gastric organoids (PDGOs)...

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Literature Corpus work: 5587ad28-8064-5f8c-951d-e44865914a06
DOI: 10.1101/2025.10.01.679809

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