BRCA2 gene mutations in families with aggregations of breast and stomach cancers.

doi:10.1038/sj.bjc.6600562

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Article

BRCA2 gene mutations in families with aggregations of breast and stomach cancers.

British journal of cancer - 7 Oct 2002

Jakubowska A, Nej K, Huzarski T, Scott R J, Lubiński J

Abstract excerpt

Stomach cancer ranks second to lung cancer in the global cancer burden. It is estimated that 25% of families meeting the criteria for hereditary diffuse gastric carcinoma (HDCG) will have germline mutations in the E-cadherin gene. Evidence suggests that stomach cancer might also be a malignant manifestation of other inherited predispositions to disease. Recently, it has been reported that the incidence of stomach...

Topics

Adult
Age of Onset
Aged
Breast Neoplasms
DNA, Neoplasm
Family
Female
Genes, BRCA2
Genetic Testing
Genotype
Humans
Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Pedigree

Phenotype

Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 12373604
DOI: 10.1038/sj.bjc.6600562
PMCID: PMC2376177

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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