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Article

Gastric cancer risk and BRCA1/2 mutations: a systematic review and meta-analysis.

Personalized medicine - 1 Aug 2025

de Moraes Francisco Cezar Aquino, Matheus Gustavo Tadeu Freitas Uchôa, Souza Maria Eduarda Cavalcanti, Burbano Rommel Mario Rodriguez

Abstract excerpt

BACKGROUND: Gastric cancer is an aggressive and heterogeneous disease, primarily sporadic, with only 1-3% of cases being hereditary. However, gastric cancer is a component of several hereditary cancer syndromes. The BRCA1 and BRCA2 genes encode key DNA repair proteins involved in homologous recombination. Studies suggest a significantly increased risk of gastric cancer in first-degree relatives of BRCA1/2...

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Identifiers

PMID: 40653790
DOI: 10.1080/17410541.2025.2531737

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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