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Article

NEIL2 plays a critical role in limiting inflammation and preserving genomic integrity in <i>H. pylori</i> -infected gastric epithelial cells

2019-07-02

Abstract excerpt

The accumulation of Helicobacter pylori infection-induced oxidative DNA damage in gastric epithelial cells is a risk factor for developing gastric cancer (GC); however, the underlying mechanisms remain poorly understood. Here we report that the suppression of NEIL2, an oxidized base-specific mammalian DNA glycosylase, is one such mechanism via which H. pylori infection may fuel the accumulation of DNA damage dur...

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Identifiers and source

Literature Corpus work
f34146fe-e0d2-5ec9-bf2d-9a0eb36a1c61
DOI
10.1101/687962
Open publication

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