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Article

Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers.

International journal of cancer - 1 Oct 2026

Buckley Kole H, Zhu Yuhan, Dinh Kevin, Hausler Ryan, Gala Rohan, Spiegel Sophia R, Delgado Rosella, Clay Daniel G, Kelly Gregory M, Brower Jamie, Domchek Susan M, Maxwell Kara N, Katona Bryson W

Abstract excerpt

Recent evidence suggests that carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 may have an increased risk of gastric cancer (GC). However, the specific mechanisms underlying gastric carcinogenesis remain uncertain. Strikingly, recent data have demonstrated that Japanese BRCA1 and BRCA2 PGV carriers with Helicobacter pylori (Hp) exposure have a substantially increased risk of GC compared to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42286806
DOI: 10.1002/ijc.70572
PMCID: PMC13432517

Genes

BRCA1
BRCA2
GC
ATM
PALB2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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