Article

In vitro diversification of chimeric human/chicken antibodies

2019-01-01

Abstract excerpt

Cells that constitutively diversify their immunoglobulin genes can be used for selection of novel antibodies and refining affinities and specificities of existing ones (Cumbers et al., 2002). The chicken derived DT40 B cell line has been adapted for the expression and diversification of humanized antibodies. Human antibodies in the form of scFvs expressed in the surface of these cells have been successfully divers...

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Literature Corpus work: 557002c7-9bb7-555b-abab-39f8757c75ed
DOI: 10.17863/cam.40560

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