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Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line.

Cellular & molecular immunology - 1 Jun 2021

Seo Hidetaka, Masuda Hitomi, Asagoshi Kenjiro, Uchiki Tomoaki, Kawata Shigehisa, Sasaki Goh, Yabuki Takashi, Miyai Shunsuke, Takahashi Naoki, Hashimoto Shu-Ichi, Sawada Atsushi, Takaiwa Aki, Koyama Chika, Tamai Kanako, Kurosawa Kohei, Lin Ke-Yi, Ohta Kunihiro, Nakazaki Yukoh

Abstract excerpt

Monoclonal antibodies (mAbs) are widely utilized as therapeutic drugs for various diseases, such as cancer, autoimmune diseases, and infectious diseases. Using the avian-derived B cell line DT40, we previously developed an antibody display technology, namely, the ADLib system, which rapidly generates antigen-specific mAbs. Here, we report the development of a human version of the ADLib system and showcase the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32457406
DOI: 10.1038/s41423-020-0440-9
PMCID: PMC8166883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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