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Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire

21 Nov 2013

Abstract excerpt

Transgenic chickens expressing human sequence antibodies would be a powerful tool to access human targets and epitopes that have been intractable in mammalian hosts because of tolerance to conserved proteins. To foster the development of the chicken platform, it is beneficial to validate transgene constructs using a rapid, cell culture-based method prior to generating fully transgenic birds. We describe a method...

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PMID: 24278246
DOI: 10.1371/journal.pone.0080108

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