Article

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

2021-12-21

Abstract excerpt

Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the mitochondrial protein CHCHD10. To understand the disease etiology, we developed a novel knock-in mouse model and found that mutant CHCHD10 aggregates in affected tissues...

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Literature Corpus work: 5c854feb-8bfc-5ef4-be19-9eaddce1b176
DOI: 10.1101/2021.12.21.473493

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