Article
Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.
Cell metabolism - 4 Mar 2014
Dogan Sukru Anil, Pujol Claire, Maiti Priyanka, Kukat Alexandra, Wang Shuaiyu, Hermans Steffen, Senft Katharina, Wibom Rolf, Rugarli Elena I, Trifunovic Aleksandra
Abstract excerpt
Adaptive stress responses activated upon mitochondrial dysfunction are assumed to arise in order to counteract respiratory chain deficiency. Here, we demonstrate that loss of DARS2 (mitochondrial aspartyl-tRNA synthetase) leads to the activation of various stress responses in a tissue-specific manner independently of respiratory chain deficiency. DARS2 depletion in heart and skeletal muscle leads to the severe...
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