Article

Antiviral defense via nucleotide depletion in bacteria

2021-04-26

Abstract excerpt

DNA viruses and retroviruses need to consume large quantities of deoxynucleotides (dNTPs) when replicating within infected cells. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the viral life cycle, and inhibits viral replication by degrading dNTPs into their constituent deoxynucleosides and inorganic phosphate. In this study we report that bacteria employ a similar strategy to defend a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55296d14-3d97-53ce-b7b6-eada6dc7923c
DOI: 10.1101/2021.04.26.441389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antiviral defense via nucleotide depletion in bacteriaDOI 10.1101/2021.04.26.441389Read

Bacteria sense virus-induced genome degradation via methylated mononucleotides.Semantic proximity Read

CBASS phage defense and evolution of antiviral nucleotide signalingSemantic proximity Read

UG/Abi: a highly diverse family of prokaryotic reverse transcriptases associated with defense functionsSemantic proximity Read

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation.Semantic proximity Read

Phage defense and genome editing using novel retrons sourced from isolated environmental bacteriaSemantic proximity Read

Activation of the DNA Damage Response by RNA VirusesSemantic proximity Read

Discovery of phage determinants that confer sensitivity to bacterial immune systems.Semantic proximity Read

Bacterial and human exonucleases mediate interkingdom antiviral immunitySemantic proximity Read

Genomes in Conflict: Maintaining Genome Integrity During Virus InfectionSemantic proximity Read

Virus DNA Replication and the Host DNA Damage ResponseSemantic proximity Read

A phage mechanism for selective nicking of dUMP-containing DNA.Semantic proximity Read

The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomesSemantic proximity Read