Article

Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria

2025-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a toxic effector. The reverse transcriptase, noncoding RNA, and RT-DNA complex sequester the toxic effector until triggered by phage infection, at whic...

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Literature Corpus work: 20095a1b-0c59-5f07-b91f-73c4708c66a4
DOI: 10.1101/2025.01.29.635429

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