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Article

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation.

Nature communications - 4 Jun 2020

Ka Donghyun, Oh Hyejin, Park Eunyoung, Kim Jeong-Han, Bae Euiyoung

Abstract excerpt

The intense arms race between bacteria and phages has led to the development of diverse antiphage defense systems in bacteria. Unlike well-known restriction-modification and CRISPR-Cas systems, recently discovered systems are poorly characterized. One such system is the Thoeris defense system, which consists of two genes, thsA and thsB. Here, we report structural and functional analyses of ThsA and ThsB. ThsA...

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Identifiers

PMID: 32499527
DOI: 10.1038/s41467-020-16703-w
PMCID: PMC7272460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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