Article

Proteomic analysis of the role of the quality control protease LONP1 in mitochondrial protein aggregation

2021-04-12

Abstract excerpt

The mitochondrial matrix protease LONP1 is an essential part of the organellar protein quality control system. LONP1 has been shown to be involved in respiration control and apoptosis. Furthermore, a reduction in LONP1 level correlates with ageing processes. Up to now, the effects of a LONP1 defect were mostly studied by utilizing transient, siRNA-mediated knockdown approaches. We generated a new cellular model sy...

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Literature Corpus work: 55108bcd-6c86-5396-b482-43b4be11f8a4
DOI: 10.1101/2021.04.12.439502

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