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Article

Emerging role of Lon protease as a master regulator of mitochondrial functions.

Biochimica et biophysica acta - 1 Aug 2016

Pinti Marcello, Gibellini Lara, Nasi Milena, De Biasi Sara, Bortolotti Carlo Augusto, Iannone Anna, Cossarizza Andrea

Abstract excerpt

Lon protease is a nuclear-encoded, mitochondrial ATP-dependent protease highly conserved throughout the evolution, crucial for the maintenance of mitochondrial homeostasis. Lon acts as a chaperone of misfolded proteins, and is necessary for maintaining mitochondrial DNA. The impairment of these functions has a deep impact on mitochondrial functionality and morphology. An altered expression of Lon leads to a...

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Identifiers

PMID: 27033304
DOI: 10.1016/j.bbabio.2016.03.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Emerging role of Lon protease as a master regulator of mitochondrial functions.PMID 27033304Read ↗

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