Article

Discovery of a protein uptake pathway in lysosomes

2020-08-11

Abstract excerpt

The degradation of cellular components plays an essential role in homeostasis. However, the known degradation pathways cannot account for the levels of proteolysis in cells. Here, we demonstrate that cytosolic proteins are imported into lysosomes in an ATP-dependent manner for degradation through a direct uptake mechanism distinct from any known pathway. SIDT2, a lysosomal membrane protein previously reported as a...

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Identifiers and source

Literature Corpus work: 86632981-7656-58bc-bb93-f0f76e6c30e4
DOI: 10.1101/2020.08.11.245688

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