Article

LONP1 is required for maturation of a subset of mitochondrial proteins and its loss elicits an integrated stress response

2018-04-23

Abstract excerpt

LONP1, a AAA+ mitochondrial protease, is implicated in protein quality control, but its substrates and precise role in this process remain poorly understood. Here we have investigated the role of human LONP1 in mitochondrial gene expression and proteostasis. Depletion of LONP1 resulted in partial loss of mtDNA, complete suppression of mitochondrial translation, a marked increase in the levels of a distinct subset...

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Literature Corpus work: d5cf3ce6-5d0d-5702-adff-fa0045f45796
DOI: 10.1101/306316

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