Article

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Proteotoxicity is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether protein misfolding in T2D is generalized or has special features. Here, we report a robust accumulation of misfolded proteins within the mitochondria of human pancreatic islets in T2D and elucidate its impact on β cell viability. Surprisingly, quantitative proteomics studies of protein aggregat...

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Literature Corpus work: 080d3892-2315-5652-947e-6690340cbeb3
DOI: 10.1101/2024.06.03.597215

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