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Article

Effect of Lon protease knockdown on mitochondrial function in HeLa cells.

Biochimie - 1 May 2014

Bayot Aurélien, Gareil Monique, Chavatte Laurent, Hamon Marie-Paule, L'Hermitte-Stead Caroline, Beaumatin Florian, Priault Muriel, Rustin Pierre, Lombès Anne, Friguet Bertrand, Bulteau Anne-Laure

Abstract excerpt

ATP-dependent proteases are currently emerging as key regulators of mitochondrial functions. Among these proteolytic systems, Lon protease is involved in the control of selective protein turnover in the mitochondrial matrix. In the absence of Lon, yeast cells have been shown to accumulate electro...

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Identifiers

PMID: 24355201
DOI: 10.1016/j.biochi.2013.12.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24355201-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Effect of Lon protease knockdown on mitochondrial function in HeLa cells.PMID 24355201Read ↗

Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death.Semantic proximity Read ↗

Emerging role of Lon protease as a master regulator of mitochondrial functions.Semantic proximity Read ↗

Proteomic analysis of the role of the quality control protease LONP1 in mitochondrial protein aggregationSemantic proximity Read ↗

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Activation of the mitochondrial protein quality control system and actin cytoskeletal alterations in cells harbouring the MELAS mitochondrial DNA mutation.Semantic proximity Read ↗

Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species.Semantic proximity Read ↗

LONP1 is required for maturation of a subset of mitochondrial proteins and its loss elicits an integrated stress responseSemantic proximity Read ↗

Global proteome of <em>LonP1</em><sup>+/-</sup> mouse embryonal fibroblasts reveals impact on respiratory chain, but no interdependence between Eral1 and mitoribosomesSemantic proximity Read ↗

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease ActivationSemantic proximity Read ↗

LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domainSemantic proximity Read ↗

Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson disease-associated DJ-1/PARK 7 missense mutantsSemantic proximity Read ↗

Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growthSemantic proximity Read ↗

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