Article
Effect of Lon protease knockdown on mitochondrial function in HeLa cells.
Biochimie - 1 May 2014
Bayot Aurélien, Gareil Monique, Chavatte Laurent, Hamon Marie-Paule, L'Hermitte-Stead Caroline, Beaumatin Florian, Priault Muriel, Rustin Pierre, Lombès Anne, Friguet Bertrand, Bulteau Anne-Laure
Abstract excerpt
ATP-dependent proteases are currently emerging as key regulators of mitochondrial functions. Among these proteolytic systems, Lon protease is involved in the control of selective protein turnover in the mitochondrial matrix. In the absence of Lon, yeast cells have been shown to accumulate electron-dense inclusion bodies in the matrix space, to loose integrity of mitochondrial genome and to be respiratory...
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