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Article

PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.

PLoS genetics - 1 Jan 2014

Thomas Ruth E, Andrews Laurie A, Burman Jonathon L, Lin Wen-Yang, Pallanck Leo J

Abstract excerpt

Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease. Previous work has shown that PINK1 is constitutively degraded in healthy cells, but selectively accumulates on the surface of depolarized mitochondria, thereby initiating their autophagic degradation. Although PINK1 is known to be a cleavage target...

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Source

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Identifiers

PMID: 24874806
DOI: 10.1371/journal.pgen.1004279
PMCID: PMC4038460

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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