Article

Phase variation of <i>Clostridioides difficile</i> colony morphology occurs via modulation of cell division

2025-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Phase variation of C. difficile colony morphology occurs via modulation of transcription cmrRST , which encodes a three-protein signal transduction system. Response regulators CmrR and CmrT promote rough colony development, cell elongation and chaining, surface motility, and disease in the hamster model of infection, while impairing swimming motility and biofilm formation. Using RNA-Seq, we id...

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Literature Corpus work: 55021c0e-3490-521e-ba9c-f48db8bf4504
DOI: 10.1101/2025.08.20.671228

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