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Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy.

PLoS pathogens - 1 May 2025

Ribis John W, Nieto César, DiBenedetto Nicholas V, Mehra Anchal, Kuhn Pola, Dong Qiwen, Nagawa Irene, El Meouche Imane, Aldridge Bree B, Dunlop Mary J, Tamayo Rita, Singh Abhyudai, Shen Aimee

Abstract excerpt

Clostridioides difficile is a gastrointestinal pathogen of both humans and agricultural animals and thus a major One Health threat. The C. difficile species consists of five main clades, with Clade 5 currently undergoing speciation from Clades 1-4. Since Clade 5 strains are highly prevalent in agricultural animals and a frequent cause of zoonotic infections, these strains may have evolved phenotypes that...

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PMID: 40397889
DOI: 10.1371/journal.ppat.1013155
PMCID: PMC12140426

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