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The pH-responsive SmrR-SmrT system modulates <i>C. difficile</i> antimicrobial resistance, spore formation, and toxin production

2023-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Clostridioides difficile is an anaerobic gastrointestinal pathogen that spreads through the environment as dormant spores. To survive, replicate, and sporulate in the host intestine, C. difficile must adapt to a variety of conditions in its environment, including changes in pH, the availability of metabolites, host immune factors, and a diverse array of other species. Prior studies showed that...

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Literature Corpus work
66d5da4c-d164-5ba0-84ea-489ea589c21d
DOI
10.1101/2023.11.02.565354
Open publication

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